Driving Physician Engagement in a Rare Pediatric Disease Through Real-World Data and Precision Outreach

The challenge

The client needed to identify and engage HCPs managing patients with a rare genetic disorder affecting multiple body systems. Due to the disease's complexity and low prevalence, timely identification of treating HCPs was critical (American Cancer Society, 2025).

Key issues:

• Difficulty identifying HCPs treating patients newly diagnosed with the disease
• Low awareness of available therapy
• Limited engagement with relevant specialists 

Business-critical impact

• Missed opportunities for therapy adoption
• Delayed treatment decisions
• Underutilization of a high-cost therapy 

External factors

• Rare disease complexity
• Fragmented care pathways
• Need for real-world evidence to support targeting 

The solution

Diaceutics deployed Physician Engage to identify and engage HCPs using real-world diagnostic signals and lab alerts.

Methodology

• Weekly alerts to identify treating HCPs
• Targeted email campaigns via trusted opt-in media partners
• Personalized educational content delivered within 24 hours
• Real-time tracking of engagement metrics

Tools used

• Physician Engage
• Real-world data analytics
• Agile campaign execution over 12 months 

Results & Impact 

A total of 121 therapy-eligible patients were identified. 

The program generated $2 million in revenue.

Why it Matters 

In rare pediatric disease, low prevalence and fragmented care pathways can make treating HCPs difficult to identify—and every delay can mean a missed opportunity for an eligible patient. Physician Engage helps you use real-world diagnostic signals to identify relevant HCPs and deliver targeted education within 24 hours, giving your teams a better opportunity to build therapy awareness, support timely treatment decisions and reach more underserved patients.

Testimonial

"The campaign helped us reach the right physicians at the right time, resulting in measurable impact on prescribing behavior and patient outcomes." —  Senior Commercial Lead, Global Pharma