Aaron is responsible for the development of laboratory relationships and agreement on commercial contracts with the labs to enhance the supply of Lab data and increase the Diaceutics Global Lab Network as well as the identification of customers’ market research needs.
Aaron has 12 years sales and marketing experience of reagents and instruments in research and diagnosis markets. Aaron has experience building and managing sales teams as well as developing relationships with KOLs.
Adam facilitates integration of multiple databases to generate simple dashboards providing real-time metrics on all patients and testing, enabling powerful analyses and insights. He has a strong background in assay development, high-throughput screening, complex data analysis, and statistics. He has written many publications and has patented an improvement to a clinical diagnostic tool that has over $10M in annual sales.
Aiya is the Financial controller placed in Belfast. The day to day duties include preparation and monitoring of external and internal financial reporting for Diaceutics. Aiya is an integral part of the Diaceutics finance team.
Amit is responsible for strategic business development and growth. His responsibilities include prospecting and qualifying new business opportunities, client relationship management and alignment with the marketing team. Amit has spent 20 years in developing and commercializing in vitro diagnostics products for cancer, infectious diseases, neurological disorders and agricultural crop protection (GMO). He has academic and professional qualifications in business administration and genetics.
Andrew is a consultant in the Engagement Management Team. He is a globally experienced analyst with particular strengths in industry and market research. He is skilled at placing governmental regulations in context.
Antonio executes secondary market research, analyses IVD and local pathology landscapes and builds relationships with KOLs. He has over 13 years experience within Autoimmunity, Molecular Biology and Immunohistochemistry and lab experiences include Immunohistochemistry and FISH; Elisa and IFA methods; Digital microscopy and Flow Cytometry
Bethany works as a Director on the Engagement Team providing tangible insights and solutions to improve precision medicine. Leveraging 8 years of clinical experience in academic and community-based laboratories and an MBA, she works to understand and overcome real-world obstacles in healthcare to enhance our clients’ companion diagnostic commercialization efforts. Her expertise is in understanding diagnostic testing methodologies and assessing strategic business implications.
Brian is responsible for generating marketing imagery and maintaining the brand guidelines for client deliverables, resources and content developed across the organization. He also works on video production and the company’s digital product platforms. Brian has academic qualifications in computing in games development and several years of professional design experience.
Catarina executes secondary market research, analyses IVD and local pathology landscapes and builds relationships with KOLs. He facilitates projects between labs and pharma to highlight the role of Dx testing in the treatment journey.
Catarina comes from a background of Business development along with years of experience working as a sales representative and product specialist for Alere.
Clair focuses on the development of laboratory networking and the understanding of testing regulations in the UK. Clair has previous experience in academic research for Cardiovascular disease & molecular oncology, followed by several years In-Vitro toxicology in industry with focus on inflammatory mediators. She has over 10 years experience in sales, covering human genetics, oncology and prenatal testing. Clair has developed and implemented commercial strategies for products in highly regulated areas and complex markets, both in the UK and Nordic region.
Damian is responsible for overseeing operational excellence across the Company. In his position he provides the leadership, management and vision necessary to ensure that the company has the proper operational controls, administrative and reporting procedures in place to effectively grow the organisation and to ensure financial strength and operating efficiency . Damian has more than 20 years’ experience in the operation design and construction of Industrial facilities across the globe, with more than 15 years specialist Pharmaceutical experience.
Daniela execute primary and secondary market research in Germany, Austria and the German Swiss Canton, overseeing execution and facilitation of market research studies, development of laboratory relationships as well as the identification of customers’ market research needs. Daniela has over 20 years’ experience in a Pathology Lab and commercial roles.
Daniela has experience of establishing relationships with new customers as well as supporting and maintaining current customers. In addition, Daniela has also planned, organised and implemented workshops at congresses and for customers.
David focuses on organizing and coordinating a portfolio of client projects and internal programs to guide the organization toward project and program efficiencies. Providing guidance to the core teams, ensuring efficient and high-quality projects are delivered while promoting the company’s goal to delight our clients. David holds a BSc in Biomedical Science and has 9 years’ experience in Project Management.
As Scientific Director, Dawn works directly with laboratories to highlight opportunities for improved testing availability. She provides face-to-face education and workshops, engaging with advisors and key opinion leaders in relevant therapeutic areas. Dawn is an HCPC-registered biomedical scientist with over 25 years’ experience in histopathology, IHC and molecular pathology. She has worked as a lab manager/senior scientific officer/director of operations and senior biomedical scientist at the NHS and in the research, independent and EQA fields. Dawn has worked in major research and academic labs and large teaching hospitals in London. She recently provided support at UK NEQAS ICC and ISH as an assessor.
As Finance Assistant,. Deborah manages the Sales Ledger, specifically raising all sales invoices and submitting these to our clients. Deborah also monitors the invoice schedule reporting daily figures to the Finance team on the periods ahead and has responsibility for credit control, new client onboarding and providing strong admin backup to the Finance Team as a whole.
Deborah has over 10 years experience within Finance and is a member of the chartered institute of Accounts.
Derek leads the Global Data Team in Diaceutics. The team has two main functions. The Analytics function provide data insights to support our project deliverables. The Engineering function are responsible for the integration of data into our global data lake and the design and development of our software products.
Derek has 19 years of professional experience across a number of roles including Engineering Development, Professional Services, Technical Sales, Product & Solution Management, Analytics & Strategy.
Over 4 years experience within the Private and Public sector. Hold First Class Honours Degree in Human Resource Management. A driven, innovative, self motivated and hard working person.
Ewelina delivers high quality actionable insights on diagnostic planning and implementation to pharmaceutical clients from multiple disease areas and in all major markets. She has academic qualifications in physiology and pharmacology and undertook post-doctoral research in Japan and the UK.
Frank has responsibility for establishing and developing client relationships for consulting projects, overseeing all aspects of project development, design, management and delivery.
Frank has more than 20 years’ experience with Diagnostic Companies dealing in client relations, product development/Launch, clinical/research studies and Data & Statistical analysis, within the space of Oncology.
Gladys is responsible for Developing, Facilitating and Maintaining laboratory relations throughout Canada. Communicating with key healthcare professionals on a daily basis along with actively participating in global secondary market research and biomaker landscaping . Gladys has over 10 years experience in biomarker research.
Glen is responsible for engaging with the Knowledge and Insights teams to understand how our customers consume our services and will be at the forefront of how that is refactored to an engaging, interactive SaaS experience for our customers which encompass data visualization and exploration. Glen has worked as a designer for over 20 years for a number of companies such as DisplayNote, Walker Communications, Cv3 and as a Freelance Designer and Consultant.
Isabel will be engaged in a variety of projects and will be assisting with data related client engagements during the initial scoping, proposal development through design, fulfilment execution and client presentation of projects. Izzy has an Integrated Masters in Mathematics and previously worked for PWC as an Investigative Analyst.
Jack engages with laboratories in the United States and Latin America creating long lasting and mutually beneficial relationships to assure data procurement, cultivation of KOLs, contracting of pathologists and other technical advisors, and education of all relevant internal and external stakeholders on predictive biomarkers and other topics of interest to our pharmaceutical clientele.
Jeff supports the team by developing relationships with laboratories in the USA. His primary role is to leverage lab resources to enable optimized diagnostic launch planning with pharma companies. Jeff has academic and professional qualifications in business development, pathology and genetics and has had commercial leadership roles with high-complexity diagnostic testing laboratories. He has focused on healthcare partnership opportunities and building strong relationships with pathologists, physicians, administrators and C-suite executives.
As part of the quality team, Jessica ensures the high quality of deliverables by checking the consistency of presentation and clarity of the message before any decks or presentation materials are released to the client. Jessica has over 3 years experience working within genetic laboratory's.
Joanne provides administrative support to Peter Krein, Jordan Clark and the wider Operations Team. She has over 8 years’ experience as an Executive Assistant working with CEOs/Directors in both the private and public sector. Joanne was recently EA to the CE of Northern Ireland’s largest private sector employer and has also worked in local government. She has academic qualifications in media studies and an LCCI Executive Secretary Diploma.
Jone focuses on the development of laboratory networking and the understanding of testing regulations in Spain. She has academic qualifications in biotechnologies and molecular medicine and a background in cancer biomarker research. She is particularly interested in molecular oncology and specialized in gastric cancer.
Joe took up the role of Key Account Director within the KAM Team in May 2019. He is based in the US. Joe has 18 years’ experience working within life science operations, selling bioinformatics portfolio of products and providing analysis and interpretation platforms for NGS based diagnostics tests. Joe has successfully built and maintained key accounts in excess of $5Million.
Joe holds an MBA in Business Administration and a MSc in Molecular Pharmacology.
Ms. Goonewardene is currently Vice Chancellor for Innovation & Strategic Investment at the University of Texas System (UTS), AMA Board, MBI Board and US Commerce Advisor. In addition, Julie has a track record as an experienced entrepreneur, having co-founded and served as President and CEO of Cantilever Technologies, a venture-backed software company that was successfully acquired. Cantilever’s customers were Fortune 500 companies. Prior to Cantilever, she was President of the Strategic Systems Group (SSG), a boutique information technology consulting firm, and co-founder of Technology Solutions (TSC), a professional IT services firm which went public three years after its inception. In addition to her role at UTS, Ms. Goonewardene is an author, frequent speaker and consultant on entrepreneurship and innovation. Based on success in these areas, Julie was elected to the Board of Trustees for the American Medical Association (AMA), the Board of Directors of the Personalized Medicine Coalition and Matrix-Bio and is an advisor on the National Advisory Council on Innovation and Entrepreneurship (NACIE) Board to the US Commerce Secretary. As a first generation American born to Sri Lankan and Australian parents, she brings a unique global perspective to her endeavours.
Karina is responsible for developing and leading Diaceutics Innovation strategy globally. Karina has a strong experience leading the Global Scientific Relation/Key Opinion Leader Program within Dako/Agilent and been responsible for implementation of several companion diagnostic tests within anatomic pathology for more than 20 years.
Kevin has over 10 years experience working the IVD industry holding various sales and marketing roles. With a focus on commercialization of CDx in alignment with Rx launch and life cycle across global territories, working on regulatory approvals of IVDs including PMAs. With his knowledge and experience of in vitro diagnostic launch planning and commercialization execution, Kevin provides insights and builds strategies for unique personalized medicine project needs.
Lauren assists the EM team with lab mapping and market research. Driving efficiencies through effective data sanity checks whilst producing accurate information for our pharma clients.
Lauren has over 8 years’ experience within a Diagnostic Genetics laboratory extracting DNA and RNA from various sample types across multiple platforms. Specialising in Cytogenetic and Molecular fields including Sanger sequencing, Microarrays, RT-PCR and ddPCR.
Lee is responsible for supporting management and delivery of client projects at Diaceutics. Lee is a chemistry graduate and a Project Management accredited PMP with over 20 years experience of complex project delivery across both the pharmaceutical and diagnostics business.
Lisa’s role within the Finance Department is to provide timely and accurate management accounts and departmental reports as well as the provision of external reports in the form of statutory accounts and filings and regular reports to funders.
Lisa is a member of the Institute of Chartered Accountants in Ireland. She has many years experience in this field having worked for Grant Thornton, Ernst & Young, UTV Media PLC and more recently C&C Group PLC.
Within the PMO Team, Louise focuses on organizing and coordinating a portfolio of client projects and internal programs to guide the organization toward project and program efficiencies. Providing guidance to the core teams, ensuring efficient and high-quality projects are delivered while promoting the company’s goal to delight our clients.
Lousie holds a BA in French and German with Marketing and has over 8 years’ Project Management experience in the UK, Japan and Singapore.
As a domain expert Lynn uses her expertise in personalized medicine, companion diagnostics, healthcare and laboratory practice to ensure timely execution of high-quality client projects.
Lynn brings over 10 years’ experience in the diagnostic industry, specializing in the field of Oncology.
Madeline is in charge of the day-to-day running of the company’s finance department and her duties include payroll, sales and purchase ledger, credit control and statutory returns. She has academic and professional qualifications in business and finance and linguistic science and has 20 years’ experience in a finance capacity with private sector businesses.
Marcos is responsible for providing understanding of the particularities of laboratories, regulation and reimbursement in Latin America. He has academic and professional qualifications in oncogenetics, molecular biology and business, and has expertise in molecular oncology tests, particularly qPCR and gene expression profiling. He has headed a molecular biology team and worked for a major clinical laboratory in Brazil.
Marianna monitors and describes the testing and reimbursement landscape in Europe, with a special focus on Italy. She has academic qualifications in biotechnologies and molecular medicine and a background in cancer research. She is particularly interested in molecular oncology and has expertise in HER2 positive breast cancer and GIST tumour.
Marianne leads the market research team, providing clear and actionable insights based on robust data related to the development and commercialization of companion diagnostics paired with targeted therapies. She has over 10 years’ global pharmaceutical market research experience, providing clients with insightful, actionable and high ROI research projects to answer key business questions in the US, European and Canadian markets.
Marieke works primarily on Diaceutics’ integrated solutions for measurement and tracking, producing data showing the current diagnostic test offering internationally. She has academic qualifications in biomedical and health sciences and science-based business.
Matthew works on Diaceutics’ software products and AWS infrastructure. He has a degree in Computer Engineering and over 8 years of professional experience across a wide range of technologies. He works on the Global Data team creating solutions to allow Diaceutics and its customers analyse data.
Mick provides systems and services to support internal business activities. He manages many of the company’s business intelligence resources and evaluates and implements technologies for the software development team. Mick has academic and professional qualifications in software engineering. He has professional experience in the fields of GIS, process engineering, lean (six-sigma), environmental protection and telecommunications.
Neil manages client projects, providing scientific and strategic insights into laboratory tests, their commercial use and integration into clinical pathways. Neil has a background in laboratory medicine and 25 years’ global experience in clinical diagnostic genetics laboratories, with a focus on oncology. He has been a UK NEQAS assessor and has written guidelines for analysis of laboratory tests. Neil has academic and professional qualifications in genetics and is a Diplomate of the Royal College of Pathologists.
As the business data analytics expert, Nital is responsibility for data related client engagements during the initial scoping, proposal development through design, fulfilment, execution and client presentation of projects. She works closely with internal analytics and the Diaceutics global data team to ensure methodologies and analytic techniques are utilized to address client’s needs.
Nital holds a Masters Degree in Pharmacy Administration as well as an MBA in Pharmaceutical Business and has previously held several senior positions within Symphony Health.
As a Diagnostic Lab Liaison, Olga works directly with laboratories to pinpoint channels where testing improvement may be applied. Olga is a biomedical scientist with over 12 years’ experience in epidemiology, infectious diseases, microbiology, cardiovascular science, inflammation, and biostatistics. She has worked as a test developer and researcher in largest research and academic institutions in Sweden and Russia. She is focusing on building long-term relationships with physicians, pathologists, laboratories in the Nordics countries.
As Chief Executive Officer of Diaceutics, Peter has driven the organization from its inception in 2005 to become a leader in innovative solutions that enable pharma to leverage diagnostic testing globally. He has overseen the expansion and development of Diaceutics to support pharma therapy and diagnostic commercialization via a worldwide team.
Peter recognized early on that precision medicine would be an increasingly large part of the drug development paradigm, representing a shift in how the pharmaceutical industry operates. Today, he is a thought leader in precision medicine commercialization and Diaceutics provides the top 20 precision medicine pharma companies with the data, analytics and global lab implementation services required to align biomarker and diagnostic demand with therapy, patient and revenue targets in key markets.
Peter’s role with Diaceutics complements over thirty years’ experience in international healthcare which began at GSK and Diagnology. He has operated and led companies and teams in the US, Europe, Asia and BRIC countries, inspiring product innovation and global launches while repeatedly delivering high corporate value growth for shareholders.
Peter has spent two extended periods in applied industrial research, including a year at MIT’s Pharmaceutical Program at the Sloan School of Management in Boston. He has also published widely and is a respected speaker at precision medicine events around the world.
Peter has responsibility for establishing and developing client relationships for consulting projects. In this role, he partners with the client and oversees all aspects of project development, design, management and delivery.
Peter has 20 years of experience in clinical diagnostics that spans across oncology, genetics and ID. Prior to joining Diaceutics, he served roles in R&D, business development and medical affairs that include IVD assay development, biomarker and molecular diagnostic technologies assessment, companion diagnostics partnership alliance management, and medical & technical education communication at Nanosphere, Abbott and Ventana.
As Chief Financial Officer of Diaceutics, Philip has responsibility for all administrative, financial and risk management operations. He works closely with the management team and Board of Directors to develop and implement strategies across the organization. In addition, Philip is responsible for maintaining compliance with US, UK and Republic of Ireland financial reporting, taxation and corporate governance standards.
Philip has over ten years’ financial and management experience as the Finance Director of a company in a global export market, as well as significant experience in product development, planning and product launch. He is an acting board member of a UK charity and has significant experience at board level in the charitable and not-for-profit sector. He is a member of the Institute of Chartered Accountants in Ireland, an associate member of the Institute of Taxation and a member of the Institute of Directors.
Piarella oversees the planning, development and execution of marketing strategy and implementation for our patient advocacy efforts. Here role empowers patients with regards to their diagnostic needs and to modify the diagnostic ecosystem with patients, and for patients. Piarella is a Patient Advocate with extensive experience in non-profit organisations at an international level.
Pilar focuses on the development of laboratory networking and the understanding of testing regulations in Spain. She has academic and professional qualifications in biochemistry, molecular biology, medical chemistry and biotechnology. Pilar has many years’ experience in oncological research, particularly in breast, colon and pancreatic tumours.
Prashanth is responsible for leading the development of Lab relations in Japan, South Korea, Thailand, ANZ and India by expanding our KOL database and facilitating the flow of Laboratory test information into the Diaceutics data ingestion engine. Prashanth has over 16 years’ experience of building innovative business in Biotechnology, Diagnostics, CRO, Medical Devices & Pharmaceutical industries.
Raymond is a PhD Graduate from Queen’s University Belfast (QUB) on a two-year placement as part of QUB’s Knowledge Transfer Project. He is responsible for performing research on healthcare economics and precision medicine, determining how better testing better treatment can lead to more efficient use of limited healthcare resources.
Ronan assists the Project Management Team in the delivery of client projects at Diaceutics.
Ronan has recently graduated with a bachelor of Science in Physics.
In his role as Software Engineer, AWS Development, Rori aims to sanitize patient level lab data and work with data transformations. He is an experienced software professional with an entrepreneurial background and over 15 years’ technical experience in both start-up and large scale enterprise environments.
As Key Account Director, Roy establishes and maintains client relationships, ensuring client satisfaction and be able to identify new opportunities and build an extensive business network within his appointed Key Clients. Roy is committed to helping clients solve problems, realise their business goals with Diaceutics solutions. Roy has over 15 years of experience in healthcare and life sciences in product marketing and sales management in APAC driving marketing strategies.
Within her role Sandrine is required to execute primary and secondary market research in France, overseeing the execution and facilitation of market research studies along with the development of laboratory relationships and the identification and implementation of customers’ market research needs.
Sarah has responsibility for all human resources operations and strategy, ensuring employment law compliance across the company. Sarah has an academic background in law and human resource management and is a member of the Chartered Institute of Personnel Development. She has 14 years’ experience in HR management across both private and public sectors, delivering strategic HR objectives to support and further corporate goals.
As Director of Marketing, Sarah is responsible for coordinating daily operations of the marketing department, managing our presence at global conferences and delivering events in collaboration with clients and laboratory partners. Sarah has postgraduate qualifications and an academic background in marketing, communications and public relations. With eight years professional experience in marketing and event management delivering corporate and non-profit sector events on a global scale, she brings a high level of experience to the growing Marketing department.
Sarah Short works within the HR, Finance and Administration teams. Sarah maintains and enhances the organization's human resources by planning, implementing and evaluating employee relations, policies, programs, and practices. She has academic and professional qualifications in HR and Business Management.
Scott’s role involves organizing and coordinating a portfolio of client projects and internal programs to guide the organization toward project and program efficiencies. He provides guidance to core teams in ways that ensure efficient and high-quality projects are delivered while promoting the company’s goal to delight our clients. He holds a BMedSc (Hons) in Medical Science and is an experienced project manager with a background in medical sciences, healthcare and clinical studies in both the NHS and Vitalograph.
Scott has recently (April 2019) taken up the role of Machine Learning Lead within the Global Data Team at Diaceutics. Scott has 8 years experience in the data field, with a masters in data science and previous to this role, held a senior position in the advanced analytics group at Seagate Technology. He has delivered on multi-million dollar ROI projects in the field of predictive machine learning and anomaly detection and is currently leading the machine learning forefront from the Diaceutics Belfast office.
Selin focuses on the development of laboratory networking, the reimbursement landscape and the understanding of testing regulations in Turkey. She has academic qualifications in medical genetics.
Selin has previous experience working in a medical genetic laboratory and as a scientific sales and application specialist.
Sery is responsible for the development of laboratory relationships and agreement on commercial contracts with the labs to enhance the supply of Lab data and increase the Diaceutics Global Lab Network as well as the identification of customers’ market research needs.
Sery has over 6 years’ experience within the Research and Commercial field. She has supported customers at planning and implementation phase as well as managing seminars and supporting customers such as pathologists.
Shilpa co-leads client projects and engages with test providers to understand the real world barriers that could impede uptake of precision medicine. Shilpa has academic and professional qualifications in biochemistry and genetics and 10 years’ experience working in a diagnostic genetics service. Her expertise is in molecular genetic laboratory techniques, particularly validation and implementation of services.
As team leader, Steve is responsible for overseeing the planning, development and execution of Diaceutics' marketing strategy and tactics. Steve drives efforts for Diaceutics to be recognized as thought leaders for the industry in precision medicine and diagnostic health. Overseeing public relations, events management and digital marketing activities, the team drives communication efforts to promote provocative perspectives in this dynamic environment.
Steve’s experience in the pharmaceutical industry includes a 12-year tenure at GlaxoSmithKline, where he supported and led US market launches of multiple brands and indications across a variety of therapeutic areas. As Director of Global Marketing, he oversaw international efforts to drive market development and lifecycle activities for the metabolic product portfolio, and spearheaded the creation of the innovation function within the US vaccines division. In addition, Steve has served as Management Advisor for TGaS Advisors, building the global marketing benchmark solution from its infancy into a standard offering for the firm.
Susanne establishes and maintains client relationships and plays a key role in the design, development, management and delivery of pharma consulting projects. Engaging with Pharmaceutical Companies, focusing on supporting and driving commercial launch excellence.
Susanne has a broad commercial work experience from both Pharma and diagnostic companies with molecular pathology, where she has led several global launches of Companion Diagnostic products. Susanne has been a leader of Global Commercial Alliances at Dako.
Tim executes primary and secondary market research in the Nordic Countries, overseeing execution and facilitation of market research studies, development of laboratory relationships as well as the identification of customers’ market research needs.
Tim has experience working in the life science industry, next generation sequencing, customer relations and technical and scientific support. Predominantly focusing on NGS products, qPCR, RNA and DNA Isolation Instrumentation mainly within the field of Oncology.
Ursula’s role covers a range of functions including Onboarding, training and development, employee relations, policies and procedures, systems updates, recruitment and probationary reviews. Ursula has over 10 years’ experience, advising and managing within the HR function, specialising in Employee Relations, Training and Learning & Development
Victoria focuses on the development of Laboratory networking and the understanding of testing regulations in the US. Victoria has over 10 years’ experience working within laboratories as well experience in technical sales and field application in the FISH/Pathology/Oncology/FFPE arena.
"I am interested in all aspects of cancer. I have been a bench tech, lead technologist, and supervisor and manager of the Cytogenetics and Molecular Cytogenetics laboratories.
My passion is identifying deficiencies and implementing process improvements for optimized productivity and customer satisfaction and retention.
I have had the great pleasure of working on many peer reviewed publications with pathologists, post doctoral fellows, vendors, and laboratory directors.
My next career goal is to obtain ceritification in Molecular Biology and sit for the certification exam MB(ASCP).
My outdoor passion is the beach and the ocean , even though living in a landlocked state does not allow me to frequent it. My favorite place to frequent is Florida.
I enjoy the ocean and the beach."
As Brand Director for Diagnostic Landscapes and Strategy, Wayne is responsible for overseeing the planning, development, and execution of the marketing strategy and implementation for the Diaceutics diagnostic landscape and data tracking products. He has a background in data and analytics to support pharma, and has held roles in pharma sales, marketing and early commercialization.
Wendy designs and codes applications that run on the web to access new Diaceutics services, such as the lab database tool. Wendy has a PhD in Cancer Drug Resistance. She has worked for Queens University Belfast for 16 years as a bioinformatician in personalised Medicine within Colo rectal Cancer.
Zarina heads the in-house legal function. She has over 12 years’ multi-jurisdictional legal experience in various industries in Singapore and the UK including financial services, oil & gas, power and media. Zarina is a qualified solicitor in England and Wales.