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Measuring What Matters: How to Track and Improve HCP Engagement ROI

19 November, 2025

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Pharma marketers are under growing pressure to prove that their campaigns do more than generate awareness, they must drive prescribing behavior, improve patient outcomes, and deliver measurable return on investment (ROI). Yet, 26% of marketers cite measuring campaign effectiveness as a top challenge, especially when trying to link spend to therapy adoption, (UP, 2024). 

In a landscape where billions are spent on HCP engagement annually, the ability to measure what truly matters is no longer optional; it’s a commercial imperative. 

Why Traditional Metrics Fall Short 

For years, pharma marketing has relied on surface-level metrics: impressions, opens, and attendance rates. These indicators offer a snapshot of reach, but they rarely reflect clinical relevance or behavioral change. As Sophie Peoples, Head of Oncology Digital Data at GSK, noted in a recent Fierce Biotech webinar, “Engagement success isn’t just about frequency—it’s about understanding how physicians interact with content and how that converts into clinical action.” 

Fierce Biotech & Diaceutics. (2025).Data-Driven Targeting and HCP Education: Engaging Physicians Within the Critical Treatment Decision Window [Webinar]. Featuring Sophie Peoples, GSK. 

 

Leading indicators like content views are useful, but lagging indicators, such as diagnostic test orders or therapy initiation, are what truly define ROI. 

A New KPI Framework for HCP Engagement 

To move beyond surface-level analytics, pharma marketers must adopt a KPI framework that links engagement to outcomes. Diaceutics recommends tracking across three tiers: 

  • Engagement Quality 

  • Content interaction rates 

  • Channel preference and responsiveness 

  • Peer-led content performance 

  • Prescriber Behavior Change 

  • Diagnostic test ordering rates 

  • Therapy initiation following engagement 

  • Shifts in prescribing patterns over time 

  • Commercial Impact 

  • Therapy adoption by region or specialty 

  • Prescription volume growth 

  • ROI per engagement touchpoint 

This framework enables marketers to connect the dots between campaign activity and clinical action, turning engagement into measurable influence. 

How Physician Engage Powers Performance 

Diaceutics’ Physician Engage platform is designed to operationalize this framework. By combining diagnostic intelligence with real-time HCP targeting, it enables: 

  • Trigger-based outreach within 24 hours of a qualifying diagnostic event 

  • Personalized content delivery aligned with the physician’s current patient context 

  • Outcome tracking that links engagement to testing and treatment decisions 

Measuring HCP engagement effectively means shifting focus from volume to value. It’s not enough to know how many physicians saw a message; we need to understand whether that message influenced their clinical thinking, prompted diagnostic action, or supported a treatment decision. This is where leading indicators like content views must be complemented by lagging indicators such as test orders and therapy starts. When engagement is aligned with clinical relevance and delivered at the right moment, it becomes a catalyst for better care, not just a marketing metric. 

Industry Insights: What the Data Tells Us 

Fierce Pharma reports that demonstrating ROI is the top challenge for digital HCP engagement, cited by 69% of pharma companies (Fierce Pharma, 2025). 

This insight underscore the urgency of building smarter measurement models, ones that reflect the complexity of the HCP journey and the real-world impact of engagement. 

Putting Patients at the Center 

Ultimately, measuring HCP engagement isn’t just about optimizing spend, it’s about ensuring that patients receive timely, appropriate care. Every click, view, or interaction should be a step toward better treatment decisions. Physician Engage helps marketers align their efforts with this goal, ensuring that every campaign contributes to meaningful clinical outcomes. 

Let’s Measure What Matters 

If your team is ready to move beyond vanity metrics and build a performance model that reflects real-world impact, Diaceutics can help.  

Reach out to explore how Physician Engage can support smarter engagement, stronger ROI, and better patient outcomes. 

About Diaceutics

At Diaceutics we believe that every patient should get the precision medicine they deserve. We are a data analytics and end-to-end services provider enabled by DXRX - the world’s first Network solution for the development and commercialization of precision medicine diagnostics. 

Diaceutics has worked on every precision medicine brought to market and provides services to 36 of the world’s leading pharmaceutical companies. We have built the world’s largest repository of diagnostic testing data with a growing network of 2500 labs in 51 countries.

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Caroline Forde
Robyn Fisher
 
Kieran Breheny